Pharmacokinetic/Pharmacodynamic (PK/PD) Model

PK/PD models describe the relation between drug dosing, concentration, and efficacy.

Pharmacokinetic/pharmacodynamics (PK/PD) modeling, an integral component of the drug development process, is a mathematical technique for predicting the effect and efficacy of drug dosing over time. Broadly speaking, pharmacokinetic models describe how the body reacts to a drug in terms of absorption, distribution, metabolism, and excretion. Pharmacodynamic models describe how a drug affects the body by linking the drug concentration to an efficacy (or safety) metric. A well-characterized PK/PD model is an important tool in guiding the design of future experiments and trials.

You can represent PK/PD models with MATLAB and SimBiology, which provide an environment that streamlines and automates the modeling process. You can:

• Import, process, and visualize time-course data
• Select a pharmacokinetic model from a library, or create mechanism-based PK/PD models using the interactive block-diagram editor
• Estimate model parameters using nonlinear regression or NLME methods
• Explore system dynamics, using parameter sweeps and sensitivity analysis
• Simulate dosing strategies and what-if scenarios

Examples and How To

• Pfizer Uses Model-Based Drug Development to Help Reduce Phase II Attrition Rates (User Story)

Pharmacokinetic/Pharmacodynamic Models

• Bacterial Growth Kinetics Under Therapy (Example)
• Systemic Renin-Angiotensin-System (RAS) (Example)
• Target–Mediated Drug Disposition (TMDD) (Example)
• Tumor Growth Kinetics Under Therapy (Example)
• Whole-Body Physiologically-based Pharmacokinetic (PBPK) (Example)

Getting Started

• Getting Started with SimBiology 5:48 (Video)
• Building a Model in SimBiology 12:56 (Video)
• Integrating PK/PD and Mechanistic Modeling with SimBiology and MATLAB (Webinar)
• Using SimBiology for Mechanism-Based PK/PD Modeling (Webinar)
• Physiologically-based Modeling of Oral Drug Absorption with SimBiology (Webinar)
• Using SimBiology for Pharmacokinetic and Mechanistic Modeling (Tutorial)

Software Reference

• Pharmacokinetic and Pharmacodynamic Modeling (Documentation)
• Pharmacokinetic Modeling (Functions)

See also: computational biology, biotech and pharmaceutical, Curve Fitting Toolbox, Statistics Toolbox, SimBiology