Pharmacokinetic/Pharmacodynamic (PK/PD) Model

Pharmacokinetic/pharmacodynamics (PK/PD) modeling, an integral component of the drug development process, is a mathematical technique for predicting the effect and efficacy of drug dosing over time. Broadly speaking, pharmacokinetic models describe how the body reacts to a drug in terms of absorption, distribution, metabolism, and excretion. Pharmacodynamic models describe how a drug affects the body by linking the drug concentration to an efficacy (or safety) metric. A well-characterized PK/PD model is an important tool in guiding the design of future experiments and trials.

You can represent PK/PD models with MATLAB and SimBiology, which provide an environment that streamlines and automates the modeling process. You can:

• Import, process, and visualize time-course data
• Select a PK model from a library, or create mechanism-based PK/PD models using the interactive block-diagram editor
• Estimate model parameters using nonlinear regression or NLME methods
• Explore system dynamics, using parameter sweeps and sensitivity analysis
• Simulate dosing strategies and what-if scenarios

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