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Multivariate normal regression with missing data
[Parameters, Covariance, Resid, Info] = ecmmvnrmle(Data, Design,
MaxIterations, TolParam, TolObj, Param0, Covar0, CovarFormat)
Data  NUMSAMPLESbyNUMSERIES matrix with NUMSAMPLES samples of a NUMSERIESdimensional random vector. Missing values are represented as NaNs. Only samples that are entirely NaNs are ignored. (To ignore samples with at least one NaN, use mvnrmle.) 
Design  A matrix or a cell array that handles two model structures:

MaxIterations  (Optional) Maximum number of iterations for the estimation algorithm. Default value is 100. 
TolParam  (Optional) Convergence tolerance for estimation algorithm based on changes in model parameter estimates. Default value is sqrt(eps) which is about 1.0e8 for double precision. The convergence test for changes in model parameters is
where Param represents the output Parameters, and iteration k = 2, 3, ... . Convergence is assumed when both the TolParam and TolObj conditions are satisfied. If both TolParam ≤ 0 and TolObj ≤ 0, do the maximum number of iterations (MaxIterations), whatever the results of the convergence tests. 
TolObj  (Optional) Convergence tolerance for estimation algorithm based on changes in the objective function. Default value is eps ∧ 3/4 which is about 1.0e12 for double precision. The convergence test for changes in the objective function is
for iteration k = 2, 3, ... . Convergence is assumed when both the TolParam and TolObj conditions are satisfied. If both TolParam ≤ 0 and TolObj ≤ 0, do the maximum number of iterations (MaxIterations), whatever the results of the convergence tests. 
Param0  (Optional) NUMPARAMSby1 column vector that contains a usersupplied initial estimate for the parameters of the regression model. 
Covar0  (Optional) NUMSERIESbyNUMSERIES matrix that contains a usersupplied initial or known estimate for the covariance matrix of the regression residuals. 
CovarFormat  (Optional) String that specifies the format for the covariance matrix. The choices are:

[Parameters, Covariance, Resid, Info] = ecmmvnrmle(Data, Design, MaxIterations, TolParam, TolObj, Param0, Covar0, CovarFormat) estimates a multivariate normal regression model with missing data. The model has the form
for samples k = 1, ... , NUMSAMPLES.
ecmmvnrmle estimates a NUMPARAMSby1 column vector of model parameters called Parameters, and a NUMSERIESbyNUMSERIES matrix of covariance parameters called Covariance.
ecmmvnrmle(Data, Design) with no output arguments plots the loglikelihood function for each iteration of the algorithm.
To summarize the outputs of ecmmvnrmle:
Parameters is a NUMPARAMSby1 column vector of estimates for the parameters of the regression model.
Covariance is a NUMSERIESbyNUMSERIES matrix of estimates for the covariance of the regression model's residuals.
Resid is a NUMSAMPLESbyNUMSERIES matrix of residuals from the regression. For any missing values in Data, the corresponding residual is the difference between the conditionally imputed value for Data and the model, that is, the imputed residual.
Another output, Info, is a structure that contains additional information from the regression. The structure has these fields:
Info.Obj – A variableextent column vector, with no more than MaxIterations elements, that contains each value of the objective function at each iteration of the estimation algorithm. The last value in this vector, Obj(end), is the terminal estimate of the objective function. If you do maximum likelihood estimation, the objective function is the loglikelihood function.
Info.PrevParameters – NUMPARAMSby1 column vector of estimates for the model parameters from the iteration just prior to the terminal iteration.nfo.PrevCovariance – NUMSERIESbyNUMSERIES matrix of estimates for the covariance parameters from the iteration just prior to the terminal iteration.
ecmmvnrmle does not accept an initial parameter vector, since the parameters are estimated directly from the first iteration onward.
You can configure Design as a matrix if NUMSERIES = 1 or as a cell array if NUMSERIES ≥ 1.
If Design is a cell array and NUMSERIES = 1, each cell contains a NUMPARAMS row vector.
If Design is a cell array and NUMSERIES > 1, each cell contains a NUMSERIESbyNUMPARAMS matrix.
These points concern how Design handles missing data:
Although Design should not have NaN values, ignored samples due to NaN values in Data are also ignored in the corresponding Design array.
If Design is a 1by1 cell array, which has a single Design matrix for each sample, no NaN values are permitted in the array. A model with this structure must have NUMSERIES ≥ NUMPARAMS with rank(Design{1}) = NUMPARAMS.
ecmmvnrmle is more strict than mvnrmle about the presence of NaN values in the Design array.
Use the estimates in the optional output structure Info for diagnostic purposes.
See Multivariate Normal Regression, LeastSquares Regression, CovarianceWeighted Least Squares, Feasible Generalized Least Squares, and Seemingly Unrelated Regression.
Roderick J. A. Little and Donald B. Rubin, Statistical Analysis with Missing Data, 2nd ed., John Wiley & Sons, Inc., 2002.
XiaoLi Meng and Donald B. Rubin, "Maximum Likelihood Estimation via the ECM Algorithm," Biometrika, Vol. 80, No. 2, 1993, pp. 267278.
Joe Sexton and Anders Rygh Swensen, "ECM Algorithms that Converge at the Rate of EM," Biometrika, Vol. 87, No. 3, 2000, pp. 651662.
A. P. Dempster, N.M. Laird, and D. B. Rubin, "Maximum Likelihood from Incomplete Data via the EM Algorithm," Journal of the Royal Statistical Society, Series B, Vol. 39, No. 1, 1977, pp. 137.