Multivariate normal regression with missing data
[Parameters,Covariance,Resid,Info] = ecmmvnrmle(Data,Design,MaxIterations,TolParam,TolObj,Param0,Covar0,CovarFormat)


 A matrix or a cell array that handles two model structures:

 (Optional) Maximum number of iterations for the estimation algorithm. Default value is 100. 
 (Optional) Convergence tolerance for estimation algorithm
based on changes in model parameter estimates. Default value is $$\Vert Para{m}_{k}Para{m}_{k1}\Vert <TolParam\times \left(1+\Vert Para{m}_{k}\Vert \right)$$ where 
 (Optional) Convergence tolerance for estimation algorithm based on changes in the objective function. Default value is eps ∧ 3/4 which is about 1.0e12 for double precision. The convergence test for changes in the objective function is $$\leftOb{j}_{k}Ob{j}_{k1}\right<\text{\hspace{0.17em}}TolObj\times \left(1+\leftOb{j}_{k}\right\right)$$ for iteration k =
2, 3, ... . Convergence is assumed when both the 
 (Optional) 
 (Optional) 
 (Optional) Character vector that specifies the format for the covariance matrix. The choices are:

[Parameters,Covariance,Resid,Info] = ecmmvnrmle(Data,Design,MaxIterations,TolParam,TolObj,Param0,Covar0,CovarFormat)
estimates
a multivariate normal regression model with missing data. The model
has the form
$$Dat{a}_{k}\sim N\left(Desig{n}_{k}\times Parameters,\text{\hspace{0.17em}}Covariance\right)$$
for samples k = 1, ... , NUMSAMPLES
.
ecmmvnrmle
estimates
a NUMPARAMS
by1
column vector
of model parameters called Parameters
, and a NUMSERIES
byNUMSERIES
matrix
of covariance parameters called Covariance
.
ecmmvnrmle(Data, Design)
with no output arguments
plots the loglikelihood function for each iteration of the algorithm.
To summarize the outputs of ecmmvnrmle
:
Parameters
is a NUMPARAMS
by1
column
vector of estimates for the parameters of the regression model.
Covariance
is a NUMSERIES
byNUMSERIES
matrix
of estimates for the covariance of the regression model's residuals.
Resid
is a NUMSAMPLES
byNUMSERIES
matrix
of residuals from the regression. For any missing values in Data
,
the corresponding residual is the difference between the conditionally
imputed value for Data
and the model, that is,
the imputed residual.
Note:
The covariance estimate 
Another output, Info
, is a structure that
contains additional information from the regression. The structure
has these fields:
Info.Obj
— A variableextent
column vector, with no more than MaxIterations
elements,
that contain each value of the objective function at each iteration
of the estimation algorithm. The last value in this vector, Obj
(end)
,
is the terminal estimate of the objective function. If you do maximum
likelihood estimation, the objective function is the loglikelihood
function.
Info.PrevParameters
— NUMPARAMS
by1
column
vector of estimates for the model parameters from the iteration just
prior to the terminal iteration.nfo.PrevCovariance
– NUMSERIES
byNUMSERIES
matrix
of estimates for the covariance parameters from the iteration just
prior to the terminal iteration.
ecmmvnrmle
does not accept
an initial parameter vector, since the parameters are estimated directly
from the first iteration onward.
You can configure Design
as a matrix if NUMSERIES
= 1
or as a cell array if NUMSERIES
≥ 1
.
If Design
is a cell array and NUMSERIES
= 1
,
each cell contains a NUMPARAMS
row
vector.
If Design
is a cell array and NUMSERIES
> 1
, each cell
contains a NUMSERIES
byNUMPARAMS
matrix.
These points concern how Design
handles missing
data:
Although Design
should not have NaN
values,
ignored samples due to NaN
values in Data
are
also ignored in the corresponding Design
array.
If Design
is a 1
by1
cell
array, which has a single Design
matrix for each
sample, no NaN
values are permitted in the array.
A model with this structure must have NUMSERIES
≥ NUMPARAMS
with rank(Design{1})
= NUMPARAMS
.
ecmmvnrmle
is
more strict than mvnrmle
about
the presence of NaN
values in the Design
array.
Use the estimates in the optional output structure Info
for
diagnostic purposes.
See Multivariate Normal Regression, LeastSquares Regression, CovarianceWeighted Least Squares, Feasible Generalized Least Squares, and Seemingly Unrelated Regression.
Roderick J. A. Little and Donald B. Rubin. Statistical Analysis with Missing Data. 2nd Edition. John Wiley & Sons, Inc., 2002.
XiaoLi Meng and Donald B. Rubin. "Maximum Likelihood Estimation via the ECM Algorithm." Biometrika. Vol. 80, No. 2, 1993, pp. 267–278.
Joe Sexton and Anders Rygh Swensen. "ECM Algorithms that Converge at the Rate of EM." Biometrika. Vol. 87, No. 3, 2000, pp. 651–662.
A. P. Dempster, N.M. Laird, and D. B. Rubin. "Maximum Likelihood from Incomplete Data via the EM Algorithm." Journal of the Royal Statistical Society. Series B, Vol. 39, No. 1, 1977, pp. 1–37.