the desktop could not fit the 3 compartment PK model.

I am starting with simbiology desktop (matlab2013)to fit my model to data.

My data is imported from a .xml file.It has group variable,independ variable, dependent variable, dose, rate,and some covariate. Data imports properly and is also plotted correctly, so I think that's not a problem.

Then I have creat a model (3 compartment blous with linear{Cl,V} only in the central compartment). The estimated object 'Cl_Central' specified in the PKModelMap does not resolve to a species, parameter, or compartment object.

So I creat a same model from PK Library, as same as the first model (3 compartment blous with linear{Cl,V}with only the central compartment). However,the model have not Cl_Central, only have Cl_Peripheral. I think there is some wrong with the simbiology.Every 2,or 3 compartment PK model must have Cl_Central. Could the SimBiology fit 3 compartment model?Or there is some bug?

I also use matlab2010 simbiology to fit my data. But it fail. "Simulation of the SimBiology model during fitting resulted in invalid values for species, compartments, or parameters in the model. This is often caused by a poorly posed regression problem. Try using different initial parameter estimates or try a different model for the data."I use some initial parameter from some paper.I think it have no problem.

Is anything I have forgot to do? I can send the files I am working with. Or could you please give me a 3 compartment model example?

Look forward to your reply. Thanks.

Answer 1

[Arthur Goldsipe]

Hi Yang,

When you specify that your model has linear{Cl,V} in the Central compartment, then a parameter named "Cl_Central" should automatically be created. I confirmed that this happens with a 3-compartment model in R2013b. Are you certain that you selected the correct compartment for clearance? You should be able to confirm that your model is configured correctly by examining the "PK View" diagram that is available in the "Create PK Model" dialog box.

I will also email you an example SimBiology project.

If you continue to have problems and you are eligible for support, I also recommend contacting MathWorks support via this link: http://www.mathworks.com/support/contact_us/index.html

-Arthur