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MGraph

from MGraph by junbai wang
Probabilistic graphical models for reconstruction of genetic regulatory networks using DNA microarra

wang_learn_struct_pdag_pc_bak(cond_indep, n, k, varargin)
function [pdag, G] = wang_learn_struct_pdag_pc_bak(cond_indep, n, k, varargin)
% LEARN_STRUCT_PDAG_PC Learn a partially oriented DAG (pattern) using the PC algorithm
% P = learn_struct_pdag_pc(cond_indep, n, k, ...)
%
% n is the number of nodes.
% k is an optional upper bound on the fan-in (default: n)
% cond_indep is a boolean function that will be called as follows:
%   feval(cond_indep, x, y, S, ...)
% where x and y are nodes, and S is a set of nodes (positive integers),
% and ... are any optional parameters passed to this function.
%
% The output P is an adjacency matrix, in which
% P(i,j) = -1 if there is an i->j edge.
% P(i,j) = P(j,i) = 1 if there is an undirected edge i <-> j
%
% The PC algorithm does structure learning assuming all variables are observed.
% See Spirtes, Glymour and Scheines, "Causation, Prediction and Search", 1993, p117.
% This algorithm may take O(n^k) time if there are n variables and k is the max fan-in,
% but this is quicker than the Verma-Pearl IC algorithm, which is always O(n^n).
%
%this program seems match with Tetrad4.2 program but some edges were missing or the direction of edges were
% not the same as Tetrad4.2 I need test more and find out way?


%Step A.B  
sep = cell(n,n);
ord = 0;
done = 0;
G = ones(n,n);
G=setdiag(G,0);
while ~done
  done = 1;
  [X,Y] = find(G); 
  for i=1:length(X)
    x = X(i); y = Y(i);
    nbrs = mysetdiff(myunion(neighbors(G, x), neighbors(G,y)), [x y]);
    if (length(nbrs) >= ord & G(x,y) ~= 0)
      done = 0;
      %SS = subsets(nbrs, ord, ord); % all subsets of size ord
      %bug 1 in subsets, now fixed by jbw 04.09.2003
      SS=wang_kSubset(nbrs,ord);
      ln_SS=size(SS,1);
      for si=1:ln_SS
        if iscell(SS)
	        S = SS{si};
        else
	        S=SS(si,:);
        end
       
        if feval(cond_indep, x, y, S, varargin{:})
	        % diagnostic
	        %[CI, r] = cond_indep_fisher_z(x, y, S, varargin{:});
	        %fprintf(': r = %6.4f\n', r);
	        G(x,y) = 0;
	        G(y,x) = 0;
	        sep{x,y} = myunion(sep{x,y}, S);
	        sep{y,x} = myunion(sep{y,x}, S);
	        %break; % no need to check any more subsets 
            %bug 2 need check all subsets jbw sep 2. 2003
	    end
      end %end subset
    end  %end if
  end %end all ordered pairs
  ord = ord + 1
end %end while

% Create the minimal pattern, step C
% i.e., the only directed edges are V structures.
pdag = G;
[X, Y] = find(G);
% We want to generate all unique triples x,y,z
% This code generates x,y,z and z,y,x.
for i=1:length(X)
  x = X(i);
  y = Y(i);
  Z = find(G(y,:));
  ZZ = mysetdiff(Z, x);
  %added jbw
  for z=ZZ(:)'  
     %end added jbw
     if (G(x,z)==0 & ~ismember(y, sep{x,z}) & ~ismember(y, sep{z,x}))
      fprintf('%d -> %d <- %d\n', x, y, z);
      pdag(x,y) = -1; pdag(y,x) = 0;
      pdag(z,y) = -1; pdag(y,z) = 0;
    end
  end
end

% Convert the minimal pattern to a complete one,
% i.e., every directed edge in P is compelled
% (must be directed in all Markov equivalent models),
% and every undirected edge in P is reversible.
% We use the rules of Pearl (2000) p51 (derived in Meek (1995))
%step D

old_pdag = zeros(n);
iter = 0;
%while ~isequal(pdag, old_pdag)
%added wang
 isempty(find(pdag==1))
while ~isempty(find(pdag==1))
  
    
  iter = iter + 1
  old_pdag = pdag;
  % rule 1 step D.1
  [A,B] = find(pdag==-1); % a -> b
  for i=1:length(A)
    a = A(i); b = B(i);
    %C = find(pdag(b,:)==1 & G(a,:)==0); % all nodes adj to b but not a 
    %wang added
    C = find(pdag(b,:)==1 & pdag(a,:)==0);
    if ~isempty(C)
      pdag(b,C) = -1; pdag(C,b) = 0;
      fprintf('rule 1: a=%d->b=%d and b=%d-c=%d implies %d->%d\n', a, b, b, C, b, C);
    end
  end
  clear A B C
  % rule 2 Step D.2 , Rule 2. 3 may unstable according to Tetrad4.2
  [A,B] = find(pdag==1); % unoriented a-b edge
  for i=1:length(A)
    a = A(i); b = B(i);
    if any( (pdag(a,:)==-1) & (pdag(:,b)==-1)' );
      pdag(a,b) = -1; pdag(b,a) = 0;
      fprintf('rule 2: %d -> %d\n', a, b);
    end
  end
  clear A B
  % % rule 3
   [A,B] = find(pdag==1); % a-b
   for i=1:length(A)
     a = A(i); b = B(i);
     %C = find( (G(a,:)==1) & (pdag(:,b)==-1)' );
     %wang added
     C = find( (pdag(a,:)==1) & (pdag(:,b)==-1)' );
     
     % C contains nodes c s.t. a-c->ba
     %G2 = setdiag(G(C, C), 1);
     %wang added
     G2=setdiag(pdag(C, C), 1);
     if any(G2(:)==0) % there are 2 different non adjacent elements of C
       pdag(a,b) = -1; pdag(b,a) = 0;
      fprintf('rule 3: %d -> %d\n', a, b);
   end
 end
end

  
pdag

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