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Using SimBiology for Mechanism-Based PK/PD Modeling in Preclinical & Discovery

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Using SimBiology for Mechanism-Based PK/PD Modeling in Preclinical & Discovery

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Examples used in the March 2012 webinar: Using SimBiology for Mechanism-Based PK/PD Modeling

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Description

View the recorded webinar here:
www.mathworks.com/company/events/webinars/wbnr60409.html

In this webinar, you learn how to use SimBiology and MATLAB to implement mechanism-based PK/PD modeling workflows. Using a modeling and simulation case-study from literature, we demonstrate:

• Building mechanism-based PK/PD models using an interactive block-diagram editor
• Estimating parameters by fitting experimental data
• Simulating different dosing strategies
• Exploring system dynamics using parameter sweeps & sensitivity analysis
• Automating and customizing analyses using MATLAB

We also highlight new features in SimBiology 2012a including:

• Simulation Viewer – a interactive visualization tool for model exploration
• Weighted fitting
• Simultaneously fitting data from multiple dose levels

Required Products Curve Fitting Toolbox
SimBiology
Statistics Toolbox
MATLAB
MATLAB release MATLAB 7.14 (R2012a)
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11 May 2012

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