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Physiologically-based Pharmacokinetic (PBPK) model for SimBiology

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Physiologically-based Pharmacokinetic (PBPK) model for SimBiology

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26 Jun 2012 (Updated )

Provides a PBPK and a Renin-Angiotensin system model for SimBiology

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Description

Provides models for Whole-Body PBPK as well as the Renin-Angiotensin System as demonstrated in the June 12th, 2012 webinar "Physiologically-based Modeling of Oral Drug Absorption with SimBiology". Requires release R2012a. The RAS and the PBPK models without the tasks are available separately for download and should work with other releases as well.

Please check the model description within the simbiology project file (display as html) for further hints on how to use the model.
Any feedback or bug reports are welcome.

Acknowledgements

This file inspired Generic Sim Biology Physiologically Based Pharmacokinetic (Pbpk) Model and Renin Angiotensin System (Ras) Model For Sim Biology.

Required Products SimBiology
Statistics Toolbox
MATLAB
MATLAB release MATLAB 7.14 (R2012a)
Other requirements C-Compiler needed for acceleration
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Comments and Ratings (2)
24 Aug 2013 Rizwan

excellent submission. Would like to see more like this.

29 Aug 2012 Sven Mesecke

The bare PBPK model that should work with recent releases is available at: http://www.mathworks.de/matlabcentral/fileexchange/37752-generic-simbiology-physiologically-based-pharmacokinetic-pbpk-model
The Renin-Angiotensin-System model can be found here: http://www.mathworks.com/matlabcentral/fileexchange/37759-renin-angiotensin-system-ras-model-for-simbiology

Updates
26 Jun 2012

*

06 Aug 2012

clarified software requirements, uploaded models that work in pre-R2012a versions of SimBiology

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