SimBiology project file and some associated MATLAB files that contain a generic and adaptable PBPK model. Human fasted, Human fed and Rat (new!) physiologies are included as variants.
Tested on R2012a and R2011b and should work with earlier releases as well. Does not contain tasks or the Renin-Angiotensin model as used in the June 2012 webinar. Please see http://www.mathworks.com/matlabcentral/fileexchange/37132-physiologically-based-pharmacokinetic-pbpk-model-for-simbiology for the project used in that webinar.
Peters, S. A. (2008). Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis. Clinical pharmacokinetics, 47(4), 261-75.
Tissue Partition Coefficients:
Rodgers, T., & Rowland, M. (2006). Physiologically Based Pharmacokinetic Modelling 2 : Predicting the Tissue Distribution of Acids , Very Weak Bases , Neutrals and Zwitterions. Journal of pharmaceutical sciences, 95(6), 1238-1257.
Rodgers, T., Leahy, D., & Rowland, M. (2005). Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases. Journal of pharmaceutical sciences, 94(6), 1259-76.