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Generic SimBiology Physiologically-based Pharmacokinetic (PBPK) model

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Generic SimBiology Physiologically-based Pharmacokinetic (PBPK) model

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29 Aug 2012 (Updated )

SimBiology implementation of a generic PBPK model. Human fasted, Human fed and Rat physiologies.

calculateParacellularAbsorption(DrugLogP, DrugMolecularWeight)
function paracellularAbsorption = calculateParacellularAbsorption(DrugLogP, DrugMolecularWeight)
% calculate the paracellular absorption rate using the heuristics presented
% in Eq. 2 in: 
% Peters, S. A. (2008). Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis. Clinical pharmacokinetics, 47(4), 261-75.
% Copyright 2012 The MathWorks, Inc.

paracellularAbsorption = 0;
if DrugLogP > 0.7, 
    paracellularAbsorption = 0; 
elseif DrugLogP < 0.1 && (DrugMolecularWeight > 200 && DrugMolecularWeight < 360), 
    paracellularAbsorption = 0.1;
elseif DrugMolecularWeight < 200,  
    paracellularAbsorption = -0.0045*DrugMolecularWeight+1;
end

%paracellularAbsorption = paracellularAbsorption*5;

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