In this tutorial, we will teach major concepts in SimBiology using simple examples of pharmacokinetic (PK) and simultaneous pharmacokinetic/pharmacodynamic (PK/PD) analyses. The example will begin with importing a PK dataset from a single subject, single oral dose study. After some basic preprocessing and visualization, we will fit the data to a one compartmental PK model with first-order dosing and linear elimination.
Next, we will combine the PK model with an indirect response PD model. We will fit a combined PK/PD dataset to this model and simultaneously estimate the PK and the PD parameters. Finally, we will use the PK/PD estimates to simulate the drug and efficacy profiles for single and repeated dose regimen.