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Thread Subject:
Pk modelling with Simbiology

Subject: Pk modelling with Simbiology

From: Sukeerthi

Date: 6 Oct, 2013 13:51:11

Message: 1 of 2

Hi,
   I am trying to simulate a PK analysis using a plasma concentrations from mice for a specific drug in Simbiology.
I wanted to ask
 1) If under the dose column in the dataset, for eg, 20 mg/kg for 0.02kg mice, the value to input is 20*0.02 milligram dose.
2) If under the concentrations in plasma, I have to enter the lg values obtained from the graph or if I have to convert the lg values to normal values before inputting them into Simbiology.

Although I have tried everything, I am unable to obtain the V, Cl, Ka and half life values from the reference paper from my model and I am unsure of where the error is in my model. No error model seems to fit well with my input data so well.

Please help!!

-Nithisha

Subject: Pk modelling with Simbiology

From: Arthur Goldsipe

Date: 7 Oct, 2013 12:57:06

Message: 2 of 2

In case anyone else sees this thread, I wanted to point out that this question has been addressed on MATLAB Answers:
http://www.mathworks.com/matlabcentral/answers/89199-regarding-pk-modelling-in-simbiology

"Sukeerthi " <princessnithisha@gmail.com> wrote in message <l2rpse$lr5$1@newscl01ah.mathworks.com>...
> Hi,
> I am trying to simulate a PK analysis using a plasma concentrations from mice for a specific drug in Simbiology.
> I wanted to ask
> 1) If under the dose column in the dataset, for eg, 20 mg/kg for 0.02kg mice, the value to input is 20*0.02 milligram dose.
> 2) If under the concentrations in plasma, I have to enter the lg values obtained from the graph or if I have to convert the lg values to normal values before inputting them into Simbiology.
>
> Although I have tried everything, I am unable to obtain the V, Cl, Ka and half life values from the reference paper from my model and I am unsure of where the error is in my model. No error model seems to fit well with my input data so well.
>
> Please help!!
>
> -Nithisha

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