SimBiology 4.0

Latest Features

Version 4.0

Released: 1 Sep 2011
 

Version 4.0, part of Release 2011b, includes the following enhancements:

• Parameter estimation performance and robustness enhancements
• Covariate modeling for nonlinear mixed-effect models
• Standard errors for nonlinear regression, including nonlinear mixed-effect models
• Sensitivity analysis for models with discontinuities

See the Release Notes for details.

Update Now

• Download the latest version if your software maintenance service is current.
• Purchase or request a renewal quote if your maintenance service has lapsed.
• Try the latest version by downloading or requesting trial software.

---

Version 3.4

Released: 8 Apr 2011
 

Version 3.4, part of Release 2011a, includes the following enhancements:

• Redesigned desktop, supporting streamlined model-building workflow, iterative workflows, and comparison of analysis results
• Arbitrary time units for simulation time
• Parameter estimation of initial conditions for species and compartments
• Robust parameter estimation
• Calculation of weighted residuals for population-fitting tasks

See the Release Notes for details.

Version 3.3

Released: 3 Sep 2010
 

Version 3.3, part of Release 2010b, includes the following enhancements:

• Support for error models when performing a population fit using the sbionlmefit or sbionlmefitsa function
• Support for covariate analysis
• Ability to simultaneously fit multiple responses
• Support for incorporating time lags for doses into models
• Dimensionless units

See the Release Notes for details.

Version 3.2

Released: 5 Mar 2010
 

Version 3.2, part of Release 2010a, includes the following enhancements:

• Stochastic approximation expectation-maximization (SAEM) algorithm for fitting of population data
• New mode for accelerating simulations
• Support for application of dosing schedules to a model
• Additional features for parameter fitting including parameter transformations, error models, and multiple dosing
• Improved support for importing NONMEM^® formatted files

See the Release Notes for details.

Version 3.1

Released: 4 Sep 2009
 

Version 3.1, part of Release 2009b, includes the following enhancements:

• Performance increase when repeatedly simulating a model with unchanged topology
• Enhanced desktop support for scanning, using Monte Carlo methods
• Support for copy and paste throughout the desktop
• Usability improvements for model building and debugging, including additional support for dynamically updated error indicators, M-lint indicators, and help for user-identified MATLAB code
• New functionality for reporting the status of a parameter fit when using nonlinear mixed effects

See the Release Notes for details.