SimBiology 4.1

Latest Features

Version 4.1

Released: 1 Mar 2012
 

Version 4.1, part of Release 2012a, includes the following enhancements:

• Configurable output times for simulation and parameter estimation
• Simultaneous fits using nonlinear regression for heterogeneously dosed patients
• Interactive Simulation Viewer to explore the effect of initial parameter, species, or compartment values on simulation results
• Weighted least squares fitting
• Support for SBML level 2 version 4

See the Release Notes for details.

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Version 4.0

Released: 1 Sep 2011
 

Version 4.0, part of Release 2011b, includes the following enhancements:

• Parameter estimation performance and robustness enhancements
• Covariate modeling for nonlinear mixed-effect models
• Standard errors for nonlinear regression, including nonlinear mixed-effect models
• Sensitivity analysis for models with discontinuities

See the Release Notes for details.

Version 3.4

Released: 8 Apr 2011
 

Version 3.4, part of Release 2011a, includes the following enhancements:

• Redesigned desktop, supporting streamlined model-building workflow, iterative workflows, and comparison of analysis results
• Arbitrary time units for simulation time
• Parameter estimation of initial conditions for species and compartments
• Robust parameter estimation
• Calculation of weighted residuals for population-fitting tasks

See the Release Notes for details.

Version 3.3

Released: 3 Sep 2010
 

Version 3.3, part of Release 2010b, includes the following enhancements:

• Support for error models when performing a population fit using the sbionlmefit or sbionlmefitsa function
• Support for covariate analysis
• Ability to simultaneously fit multiple responses
• Support for incorporating time lags for doses into models
• Dimensionless units

See the Release Notes for details.

Version 3.2

Released: 5 Mar 2010
 

Version 3.2, part of Release 2010a, includes the following enhancements:

• Stochastic approximation expectation-maximization (SAEM) algorithm for fitting of population data
• New mode for accelerating simulations
• Support for application of dosing schedules to a model
• Additional features for parameter fitting including parameter transformations, error models, and multiple dosing
• Improved support for importing NONMEM^® formatted files

See the Release Notes for details.