Import Data
Import tabular data from files to estimate model parameters. Supported file types include Excel®, text, SAS® XPORT, and NONMEM®-formatted files. Visualize and categorize the data in the SimBiology Model Analyzer app or at the command line. Use the time course data of measured drug concentrations to perform noncompartmental analysis (NCA) and calculate PK parameters.
Apps
SimBiology Model Builder | Build QSP, PK/PD, and mechanistic systems biology models interactively |
SimBiology Model Analyzer | Analyze QSP, PK/PD, and mechanistic systems biology models |
Functions
groupedData2table | Convert groupedData object to table |
sbionca | Compute noncompartmental analysis (NCA) parameters (requires Statistics and Machine Learning Toolbox) |
sbioncaoptions | Specify options to calculate noncompartmental analysis (NCA) parameters |
sbionmimport | Import NONMEM-formatted data |
sbionmfiledef | NONMEM file definition object for sbionmimport |
sbiotrellis | Plot data or simulation results in trellis plot |
sbioplot | Plot simulation results in one figure |
sbiosubplot | Plot simulation results in subplots |
Objects
groupedData | Table-like collection of data and metadata |
SimData | Simulation data |
Examples and How To
App Workflow
- Calculate NCA Parameters and Fit Model to PK/PD Data Using SimBiology Model Analyzer App
Perform noncompartmental analysis and calibrate model parameters by fitting to experimental PKPD data using nonlinear regression.
Programmatic Workflow
- Importing Data
SimBiology lets you import tabular data from external sources programmatically.
Concepts
- Importing Data — Supported Files and Data Types
SimBiology lets you import external data saved in several file formats, such as Excel files, text files, and NONMEM-formatted files.
- Noncompartmental Analysis
NCA (noncompartmental analysis) lets you calculate pharmacokinetic parameters of a drug without requiring the assumption of a compartmental model.