How to make a single REST call to get multiple channels of data

I'd like to use REST to get multiple channels of data. I am collecting data for 50 different channels and I'd like to avoid making 50 REST GET calls to get that data. Is this possible with REST? I've read about the MTU? object? Is that somthing that pertains to REST? If it's not possible with REST, should I use a different interface to get that data?

[Christopher Stapels]

This is an interesting use case. Can you tell us more about the workflow? Do you need to read from all 50 channels frequently or sporadically? Are you reading data to do a computation, or just checking the values for a threshold?