If the badly-named "A" represents a color image, then A(:, :, 1) would mean all rows and all columns in the first image plane - in other words, the red channel of the image. The code mean(mean(A(:,:,1))) would mean the average intensity of the red channel:
meanRed = mean(mean(A(:,:,1)));
Stephen and I are guessing because the author just used a single letter of the variable rather than some descriptive name would would give us some context as to what "A" represents. I hate code that just looks like a random alphabet soup of single letter variables - it makes it very hard to understand, follow, and maintain. For example if the variable were named rgbImage, then we'd know what "A" represented. As of now, we don't. You didn't supply any context either so we're left to speculate (or just ignore the question which is probably what most people did).