Need help with modeling on simbiology!!
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Hi,
I have a protein which only gets activated when three different binding sites on DNA are all bound; however, the three sites are independent and interacting (so binding on one site affects binding in the next one differently).. I've attached a picture that might help to see the three layers of reactions (or it might be just confusing, in which case, you can just ignore it!)
I'm trying to do a parameter scan to find cooperativity in this system, but I'm kind of stuck... I don't know how to figure out the values for the binding constants in such as way as to achieve cooperativity? Is it mostly guess and check or am I missing something in simbiology that I can use the help me find the cooperativity factor?
If something is unclear, please ask and I will try to answer it best I can!
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pfb
on 29 Apr 2015
You have attached no picture.
Anyway, this is a matlab forum. How is this related to matlab?
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