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Simultaneous Fit of IV and PO data using SimBiology

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Engie Salama
Engie Salama on 23 Jun 2020
Commented: Engie Salama on 1 Jul 2020
Hello,
I was wondering if there was a way to model both IV and PO data simultaneously for the same patients using SimBiology; I've successfully fitted the IV data in one model and the PO data using the same model but with different initial estimates, but I was wondering if it's possible to do one fit for both datasets. I get an error when I try to do both because the time course for the IV data and the PO data uses the same scale (0-144 hours)
Thanks in advance!

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Answers (1)

Arthur Goldsipe
Arthur Goldsipe on 24 Jun 2020
Yes, it is possible to fit two model outputs at the same time. Do you want to do this using sbiofit or a fit program in the SimBiology Analysis app? Here's an example of a simultaneous fit to two different compartments.
I don't understand what you mean about getting an error because the data uses the same time scale. If you can share some more details (the exact error message and how to reproduce it), then we should be able to help you.

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Engie Salama
Engie Salama on 1 Jul 2020
Thank you! It was able to run when I sorted the data as you suggested, but then I got one fit for each patient even though there are two curves: one for IV and one for PO. Is there a way to get fits for each curve separately? At this point, I was just going to rename the patient IDs as 100001A for IV and 100001B for PO...
Arthur Goldsipe
Arthur Goldsipe on 1 Jul 2020
Ah, sorry. I thought IV and PO represented different measurements taken during the same treatment of a patient. I looked up the term "PO" and now understand that this is a different dosing administration scheme and is associate with a different time course of measurements.
In that case, I would do exactly as you propose: Create a new label that is unique for each combination of patient and dose.

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