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The COnstraint-Based Reconstruction and Analysis Toolbox

version 3.0.4 (44.1 MB) by laurentheirendt
Creation and analysis of biochemical constraint-based models: the COBRA Toolbox v3.0


Updated 14 Mar 2019

GitHub view license on GitHub

The COnstraint-Based Reconstruction and Analysis Toolbox is a MATLAB software suite for quantitative prediction of cellular and multicellular biochemical networks with constraint-based modelling. It implements a comprehensive collection of basic and advanced modelling methods, including reconstruction and model generation as well as biased and unbiased model-driven analysis methods.

It is widely used for modelling, analysing and predicting a variety of metabolic phenotypes using genome-scale biochemical networks.

-- Manuscript available under

Cite As

Laurent Heirendt & Sylvain Arreckx, Thomas Pfau, Sebastian N. Mendoza, Anne Richelle, Almut Heinken, Hulda S. Haraldsdottir, Jacek Wachowiak, Sarah M. Keating, Vanja Vlasov, Stefania Magnusdottir, Chiam Yu Ng, German Preciat, Alise Zagare, Siu H.J. Chan, Maike K. Aurich, Catherine M. Clancy, Jennifer Modamio, John T. Sauls, Alberto Noronha, Aarash Bordbar, Benjamin Cousins, Diana C. El Assal, Luis V. Valcarcel, Inigo Apaolaza, Susan Ghaderi, Masoud Ahookhosh, Marouen Ben Guebila, Andrejs Kostromins, Nicolas Sompairac, Hoai M. Le, Ding Ma, Yuekai Sun, Lin Wang, James T. Yurkovich, Miguel A.P. Oliveira, Phan T. Vuong, Lemmer P. El Assal, Inna Kuperstein, Andrei Zinovyev, H. Scott Hinton, William A. Bryant, Francisco J. Aragon Artacho, Francisco J. Planes, Egils Stalidzans, Alejandro Maass, Santosh Vempala, Michael Hucka, Michael A. Saunders, Costas D. Maranas, Nathan E. Lewis, Thomas Sauter, Bernhard Ø. Palsson, Ines Thiele, Ronan M.T. Fleming, Creation and analysis of biochemical constraint-based models: the COBRA Toolbox v3.0, Nature Protocols, volume 14, pages 639–702, 2019

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Update of citation as paper has been accepted.

MATLAB Release Compatibility
Created with R2018b
Compatible with R2014b to any release
Platform Compatibility
Windows macOS Linux

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