A mathematical compartmental formulation of dose-effect synergy modelling for multiple therapies in non small cell lung cancer (NSCLC): antiangiongenic, immuno and radiotherapy. The model formulates the dose-effect relationship in a unified context, with tumor
proliferating rates and necrotic tissue volume progression as a function of therapy management profiles. The model accounts for inter- and intra-response variability by using surface model response terms. Slow acting peripheral compartments such as fat and muscle for drug distribution are not modelled. This minimal pharmacokinetic-pharmacodynamic (PKPD) model is evaluated with reported data in mice from literature.
Clara Mihaela Ionescu (2022). PKPDmodelNSCLC (https://www.mathworks.com/matlabcentral/fileexchange/76838-pkpdmodelnsclc), MATLAB Central File Exchange. Retrieved .
Citation: Clara Mihaela Ionescu *, Maria Ghita, Dana Copot, Eric Derom, Dirk Verellen. A minimal PKPD interaction model for evaluating synergy effects of combined NSCLC therapies, Journal of Clinical Medicine 2020, No. 5; doi:10.3390/jcmxx010005
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