How to quantify the difference between two image stacks?

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Hi, I want to quantify the registration efficacy of two 3D image stacks. Is there a function that can quantify this? For now I have to do average projection of xy, yz, and xz plane and compare their absolute difference with imabsdiff. https://www.mathworks.com/help/images/ref/imabsdiff.html Thanks!
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Yajie Liang
Yajie Liang on 16 Apr 2020
actually, the real question is how to quantify the quality of 3d image registration. For example, how much percentage of the volume is overlapped.

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