This approach maps the colour distribution of an over/under stained image to that of a well stained target image. Reinhard presented a method for matching the colour distribution of an image to that of a target image by use of a linear transform in a perceptual colourspace (the lαβ colourspace of Ruderman et al. ) so as to match the means and standard deviations of each colour channel in the two images in that colourspace.
 Derek Magee, Darren Treanor, Doreen Crellin, Mike Shires, Katherine Smith, Kevin Mohee, and Philip Quirke.:Colour normalization in digital histopathology images.
 Reinhard, E., Adhikhmin, M., Gooch, B., Shirley, P.: Color transfer between images.