Starting in R2019b, program files larger than approximately 128 MB do not open or run. For files that contain only code (for example, .m and .p files), this limit affects the file size. For files that store more than just code (for example, .mlx files), it affects the size of the code. Running statements larger than 128 MB, either directly in the Command Window or using the eval function, also is not supported. In addition, code with high levels of complexity, such as a large number of deeply nested if statements, is not supported.
Large program file or statement sizes could result in unpredictable behavior and often occurred when using large portions of code (for example, over 500 lines) to define variables with constant values. To decrease the size of program files, consider defining the variables and saving them in a data file (for example, a MAT-file or .csv file). Then you can load the variables instead of executing code to generate them. This adjustment not only decreases the file size of your program but also can increase performance.