Benchmark simulator for continuous manufacturing

A comprehensive benchmark simulator for systematic analysis, design and evaluation of different control strategies.

Nowadays pharmaceutical industry is experiencing a paradigm shift from batch to continuous manufacturing. This will lead to increased flexibility to target diverse populations as well as more consistent product quality to ensure best efficacy. Continuous processing integrated with online/inline monitoring tools coupled with an efficient automatic feedback control system is highly desired by the pharmaceutical industry. To facilitate the transition from the batch wise production to continuous manufacturing in the pharma industry engineering tools are needed. Hence, the aim of this open source simulator is to enhance the advantage of modeling and control techniques in the field of pharmaceutical applications.

D. Malevez and D. Copot, “From batch to continuous tablet manufacturing : a control perspective,” in IFAC PAPERSONLINE, Ghent, BELGIUM, 2021, vol. 54, no. 15, pp. 562–567.