The intrinsic connectivity contrast (ICC) is a measure of degree centrality for weighted networks. The ICC for a given voxel i is the average of the squared correlation values of the voxel i time series with that of every other voxel (i.e., ICC = mean(r.^2)). This function enables rapid computation of the ICC on extremely large resting-state fMRI datasets, including cases in which explict calculation of the full correlation matrix is prohibitive, whether due to RAM or computation time limitations.
*Intrinsic Connectivity Contrast References:
Martuzzi, R., Ramani, R., Qiu, M., Shen, X., Papademetris, X., & Constable, R. T. (2011). A whole-brain voxel based measure of intrinsic connectivity contrast reveals local changes in tissue connectivity with anesthetic without a priori assumptions on thresholds or regions of interest. Neuroimage, 58(4), 1044-1050.
Whitfield-Gabrieli, S., & Nieto-Castanon, A. (2012). Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain connectivity, 2(3), 125-141.
Note: for implementation details, see Whitfield-Gabrieli & Nieto-Castanon (2012) Appendix A.2: Computing Voxel-Wise Linear Functional Connectivity Measures Singular Value Decomposition
Elliot Layden (2021). intrinsic_connectivity_contrast (https://www.mathworks.com/matlabcentral/fileexchange/68248-intrinsic_connectivity_contrast), MATLAB Central File Exchange. Retrieved .
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