PKPDmodelNSCLC

version 1.0.0 (3.77 KB) by Clara Mihaela Ionescu
Mathematical compartmental formulation of dose-effect synergy modelling for multiple therapies in non small cell lung cancer (NSCLC)

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Updated 11 Jun 2020

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A mathematical compartmental formulation of dose-effect synergy modelling for multiple therapies in non small cell lung cancer (NSCLC): antiangiongenic, immuno and radiotherapy. The model formulates the dose-effect relationship in a unified context, with tumor
proliferating rates and necrotic tissue volume progression as a function of therapy management profiles. The model accounts for inter- and intra-response variability by using surface model response terms. Slow acting peripheral compartments such as fat and muscle for drug distribution are not modelled. This minimal pharmacokinetic-pharmacodynamic (PKPD) model is evaluated with reported data in mice from literature.

Cite As

Clara Mihaela Ionescu (2022). PKPDmodelNSCLC (https://www.mathworks.com/matlabcentral/fileexchange/76838-pkpdmodelnsclc), MATLAB Central File Exchange. Retrieved .

Citation: Clara Mihaela Ionescu *, Maria Ghita, Dana Copot, Eric Derom, Dirk Verellen. A minimal PKPD interaction model for evaluating synergy effects of combined NSCLC therapies, Journal of Clinical Medicine 2020, No. 5; doi:10.3390/jcmxx010005

MATLAB Release Compatibility
Created with R2017b
Compatible with R2017b to R2020a
Platform Compatibility
Windows macOS Linux
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