Parameter estimation of non linear differential equation

I have a non linear differential equation, I need to optimize its parameters.

temp=@(c,t)((1/V0)*(((1/R)*sin(t))+((1/R2)*cos(t))-c*((R+R2)/(R*R2))));

[t yNew]=ode45(temp,t,c0);

What is the best wat to estimate its parameters R and R2

[Walter Roberson]

https://www.mathworks.com/matlabcentral/answers/101883-how-do-i-estimate-or-optimize-the-parameters-of-my-ode-system-in-matlab-8-1-r2013a