I don't believe so, at least not via a global operation, since the noise is likely very close to the local means. So you can't just look at the histogram and say all bright stuff is noise. Perhaps you can use a scanning method where you're looking at the histogram just in a local area and looking for outliers, like a sigma filter or something. There are some very good noise filters out there. For example, you might want to check out imnlmfilt() to do a non-local means noise reduction.