Cystic Fibrosis, Genetics Probability Models
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1. By examining Dick's family history, it has been determined that the probability that he carries the recessive allele responsible for cystic fibrosis is 1/6. Similarly, Jane's chance of being Cc is 1/3. (a) Find the probability that both Dick and Jane are carriers of the allele. (b) Find the probability of their producing a child with cystic fibrosis
2. Suppose that you have a batch of red-flowering pea plants of which 40% are of genotype CC and 60% of genotype Cc. You pick one plant at random and cross it with a white-flowering pea plant. Find the probability that the offspring of this cross will have white flowers. (6 points) 3.(a) Use the Hardy-Weinberg model to estimate the proportion of carriers in a given population. Each genetic disease is due to the presence of two recessive alleles. (a) Cystic fibrosis occurs in approximately 1 out of every 1600 births in the United States. (b) In the Jewish population of northern Europe, Tay-Sachs disease has an incidence rate of 1 in 6000. Albinism among the Indians on the San Blas Islands off Panama occurs with probability 1/130.
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Jack Miller
on 19 Apr 2013
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