pEpitope Calculator
Estimates vaccine efficacy/effectiveness by calculating the pEpitope distance between influenza vaccine and dominant circulating strains.
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The user inputs amino acid sequences of the influenza hemagglutinin (HA) protein for the vaccine and dominant circulating strains. The value of pEpitope is calculated based on substitutions in the dominant epitope. Substitutions in all epitopes are displayed. Vaccine efficacy/effectiveness (VE) is predicted based on test-negative design studies from the Centers for Disease Control and Prevention (CDC) United States Vaccine Effectiveness Network or based on studies over the past decade from national influenza surveillance networks in the northern hemisphere (NH).
Cite As
Bonomo, Melia E., et al. “Modular Epitope Binding Predicts Influenza Quasispecies Dominance and Vaccine Effectiveness: Application to 2018/19 Season.” Vaccine, vol. 37, no. 24, Elsevier BV, May 2019, pp. 3154–58, doi:10.1016/j.vaccine.2019.03.068.
General Information
- Version 2.2 (191 KB)
MATLAB Release Compatibility
- Compatible with R2012b and later releases
Platform Compatibility
- Windows
- macOS
- Linux
