pEpitope Calculator

Version 2.2 (191 KB) by Melia Bonomo

Estimates vaccine efficacy/effectiveness by calculating the pEpitope distance between influenza vaccine and dominant circulating strains.

https://meliabonomo.com/portfolio/influenza/

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Updated 2 Dec 2020

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The user inputs amino acid sequences of the influenza hemagglutinin (HA) protein for the vaccine and dominant circulating strains. The value of pEpitope is calculated based on substitutions in the dominant epitope. Substitutions in all epitopes are displayed. Vaccine efficacy/effectiveness (VE) is predicted based on test-negative design studies from the Centers for Disease Control and Prevention (CDC) United States Vaccine Effectiveness Network or based on studies over the past decade from national influenza surveillance networks in the northern hemisphere (NH).

Cite As

Bonomo, Melia E., et al. “Modular Epitope Binding Predicts Influenza Quasispecies Dominance and Vaccine Effectiveness: Application to 2018/19 Season.” Vaccine, vol. 37, no. 24, Elsevier BV, May 2019, pp. 3154–58, doi:10.1016/j.vaccine.2019.03.068.

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MATLAB Release Compatibility

Created with R2018a

Compatible with R2012b and later releases

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Windows macOS Linux

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Version	Published	Release Notes
2.2	2 Dec 2020	New screenshot added to File Exchange	Download
2.1	2 Dec 2020		Download

MLA	Bonomo, Melia E., et al. “Modular Epitope Binding Predicts Influenza Quasispecies Dominance and Vaccine Effectiveness: Application to 2018/19 Season.” Vaccine, vol. 37, no. 24, Elsevier BV, May 2019, pp. 3154–58, doi:10.1016/j.vaccine.2019.03.068.
APA	Bonomo, M. E., Kim, R. Y., & Deem, M. W. (2019). Modular epitope binding predicts influenza quasispecies dominance and vaccine effectiveness: Application to 2018/19 season. Vaccine, 37(24), 3154–3158. Elsevier BV. Retrieved from https://doi.org/10.1016%2Fj.vaccine.2019.03.068
BibTeX	@article{Bonomo_2019, doi = {10.1016/j.vaccine.2019.03.068}, url = {https://doi.org/10.1016%2Fj.vaccine.2019.03.068}, year = 2019, month = {may}, publisher = {Elsevier {BV}}, volume = {37}, number = {24}, pages = {3154--3158}, author = {Melia E. Bonomo and Rachel Y. Kim and Michael W. Deem}, title = {Modular epitope binding predicts influenza quasispecies dominance and vaccine effectiveness: Application to 2018/19 season}, journal = {Vaccine} }

pEpitope Calculator

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MATLAB Release Compatibility

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