Continuous vs Discrete Dosing in SimBiology

I am using SimBiology and want to administer a dose continuously instead of discretely. 

1) How can I define the duration of a continuous dosing? For example, I want to have dosing from t=0 to t=2 while the simulation time is 24 hours (from t=0 to t=24). In other word, after 2 hours of dosing simulation runs for 22 hours.

2) Alternatively, how can I administer a continuous dosage throughout the entire duration of my simulation? 

3) Lastly, how can I administer a a dosage at a particular instance in time? For example, over 24 hours I want all the dosage to be in one instance of time at every hour with none of it between each hour. 

Answer 1

[MathWorks Support Team]

1) The RepeatDose (or ScheduleDose) allows you to do this.

If you want to give an infusion at a rate of 3 milligram/hour for 2 hours. That would mean that you give a total dose of 6 milligrams. You would create a dose with the following:

• Rate = 3
• RateUnits = milligram/hour
• Amount = 6
• AmountUnits = milligram

SimBiology automatically takes care of ensuring that this is done continuously through the given time. A totaly of 7 milligrams will be continuously distributed. 

2) Use a repeat or scheduled dose with just one dose starting at t=0. You can set the 'rate' parameter to the rate you need and set the 'amount' parameter to a large number. This way, the total amount will never be reached and the dose is given continuously. Your 'amount' should be larger than 'rate*(duration of simulation)'

3) The way that you can make this instantaneous is to set the 'rate' to a value of '0'.