Model, simulate, and analyze biological systems

SimBiology® provides an app and programmatic tools to model, simulate, and analyze dynamic systems, focusing on pharmacokinetic/pharmacodynamic (PK/PD) and systems biology applications. It provides a block diagram editor for building models, or you can create models programmatically using the MATLAB® language. SimBiology includes a library of common PK models, which you can customize and integrate with mechanistic systems biology models.

A variety of model exploration techniques let you identify optimal dosing schedules and putative drug targets in cellular pathways. SimBiology uses ordinary differential equations (ODEs) and stochastic solvers to simulate the time course profile of drug exposure, drug efficacy, and enzyme and metabolite levels. You can investigate system dynamics and guide experimentation using parameter sweeps and sensitivity analysis. You can also use single subject or population data to estimate model parameters.


Building Models

Represent a model of a biological or a pharmacological mechanism just as you would draw it on a piece of paper.

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Simulating Models

Simulate the dynamic behavior of your model using a variety of deterministic and stochastic solvers.

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Estimating Parameters

Estimate model parameters by fitting the model to experimental time-course data.

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Analyzing Models

Perform sensitivity analysis, parameter sweeps, and Monte Carlo simulations to explore the influence of parameters and conditions on model behavior.

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Deploying Models

Deploy models as a part of a standalone application or a software component.

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Product Resources

Discover more about SimBiology by exploring these resources.


Explore documentation for SimBiology functions and features, including release notes and examples.


Browse the list of available SimBiology functions.

System Requirements

View system requirements for the latest release of SimBiology.

Technical Articles

View articles that demonstrate technical advantages of using SimBiology.

User Stories

Read how SimBiology is accelerating research and development in your industry.

Community and Support

Find answers to questions and explore troubleshooting resources.


SimBiology apps enable you to quickly access common tasks through an interactive interface.

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Have Questions?


Contact Fulden Buyukozturk,
SimBiology Technical Expert

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SimBiology requires: MATLAB

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