Hi, all
Recently I read the book "Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry" and find this state,"Since the unbound concentrations in plasma and blood are expected to be the same, fub , fup , and R are related as follows: R=Cb/Cp=(Cub·fup)/(Cup·fub) and R=fup/fub". I don't know whether it is reasonable to generally assume unbound concentrations in plasma and blood to be the same since components in whole blood and plasma are not the same. Is it common to see this equality in real situation?
Thanks for comment.
2 Comments
Time Descending
Hi Wei,
It is generally assumed that those two unbound concentrations are the same unless there is active transport and/or irreversible binding in the tissue (in this case blood).
Below are a few publications that explore this topic:
Hi, Fulden
Thanks for your guide, that's really helpful.
